Candida parapsilosis, an Emerging Fungal Pathogen
نویسندگان
چکیده
INTRODUCTION .......................................................................................................................................................606 PREVALENCE ............................................................................................................................................................607 RISK FACTORS .........................................................................................................................................................607 CLINICAL MANIFESTATIONS ..............................................................................................................................608 Fungemia..................................................................................................................................................................608 Endocarditis.............................................................................................................................................................611 Meningitis ................................................................................................................................................................611 Peritonitis.................................................................................................................................................................611 Arthritis....................................................................................................................................................................612 Ocular Infections ....................................................................................................................................................612 Otomycosis ...............................................................................................................................................................613 Onychomycosis ........................................................................................................................................................613 Vulvovaginitis ..........................................................................................................................................................614 Urinary Tract Infections ........................................................................................................................................614 VIRULENCE FACTORS............................................................................................................................................615 Adherence.................................................................................................................................................................615 Biofilm Formation...................................................................................................................................................615 Secreted Enzymes....................................................................................................................................................616 Secreted aspartic proteinases............................................................................................................................616 Phospholipases ....................................................................................................................................................616 Lipases..................................................................................................................................................................616 ANTIMICROBIAL SUSCEPTIBILITY....................................................................................................................617 GENETICS ..................................................................................................................................................................618 Molecular Manipulations ......................................................................................................................................619 CONCLUSIONS .........................................................................................................................................................619 ACKNOWLEDGMENTS ...........................................................................................................................................619 REFERENCES ............................................................................................................................................................619
منابع مشابه
Candida parapsilosis: an emerging fungal pathogen
SUMMARY Candida parapsilosis is an emerging major human pathogen that has dramatically increased in significance and prevalence over the past 2 decades, such that C. parapsilosis is now one of the leading causes of invasive candidal disease. Individuals at the highest risk for severe infection include neonates and patients in intensive care units. C. parapsilosis infections are especially assoc...
متن کاملCandida parapsilosis of the nail-bed without onychomycosis.
Candida parapsilosis is an emerging fungal pathogen that was once thought to be solely a colonizing organism. C. parapsilosis is increasingly becoming reported as the most common Candida species that causes onychomycosis. Clinical findings include typically severe dystrophy of the nail fold and plate as well as thickening and fragmentation of the plate, particularly in the distal plate. We pres...
متن کاملRole of Protein Glycosylation in Candida parapsilosis Cell Wall Integrity and Host Interaction
Candida parapsilosis is an important, emerging opportunistic fungal pathogen. Highly mannosylated fungal cell wall proteins are initial contact points with host immune systems. In Candida albicans, Och1 is a Golgi α1,6-mannosyltransferase that plays a key role in the elaboration of the N-linked mannan outer chain. Here, we disrupted C. parapsilosis OCH1 to gain insights into the contribution of...
متن کاملCandida auris, an Emerging Fungal Pathogen
The emerging pathogen “Candida auris” is attracting considerable international attention due to its rising reports, transmission through health professionals, high rate of treatment failure and resistance to multiple antifungal agents, particularly fluconazole. In spite of the global emergence of C. auris, epidemiological data and true prevalence of infections due to this organism are not clear...
متن کاملFungal Prosthetic Valve Endocarditis by Candida parapsilosis: A Case Report
INTRODUCTION Fungal prosthetic valve endocarditis (PVE) is rare but serious complication of valve replacement surgery. Candida species, particularly Candida albicans is the most common isolated pathogen in fungal PVE (1-6%of cases). CASE PRESENTATION We describe a 35-year-old woman who underwent mechanical mitral valve replacement about 3 years ago. She was admitted with neurological symptoms...
متن کامل